电影《家庭主妇否定式》基于大热舞台剧《家庭主妇的独白》改编。两姐妹和她们的母亲原本拥有很大分歧，但是因对家、对生活的反思，暂时搁置。Gijsje是一位年轻、野心勃勃的控制狂。她非常渴望怀孕，也非常希望在广告公司获得晋升。她的姐姐Marjolein已经结婚，是三个孩子的妈妈，她刚丢了份记者的工作。不过她有了新的抱负，当一名接送孩子上下课的妈妈。她们波西米亚的母亲Loes在她漂亮的房子上借了不少贷款，给自己带来了麻烦。两姐妹不想失去他们的家庭，开始寻找拯救的方法。只有靠Gijsje想广告的金点子才能缓解他们的财政危机。这意味着她要与她迷人的同事Dominique探讨“现代家庭主妇”这个概念。这个任务比很多人想的要复杂的多。Twosistersandtheirmotherareforcedtosetasidetheirdifferencesastheyreflectonthelivestheyarelivingandthehomestheyarerunning.Gijsjeisayoung,ambitiouscontrolfreakwhoisdesperatetogetpregnantandclimbtheladderattheadvertisingagencywheresheworks.HeroldersisterMarjoleinismarriedwiththreekidsandhasjustlostherjobasajournalist.Hernewambition:tobecomeaschoolrunmum.TheirbohemianmotherLoeshasgotherselfintotroublebytakingouttoomanymortgagesonherbeautifulhome.GijsjeandMarjoleincannotbeartolosetheirfamilyhomeandstartlookingforawaytosaveit.OnlythebonusthatGijsjecanearnbycomingupwiththegoldenideaforanadvertisingcampaigncangetthemoutoffinancialtrouble.ThismeansworkingwithherattractivecolleagueDominiquetoexploretheconceptofthe"moderndayhousewife";ataskthatdredgesupalotmorethanthewomeneverbargainedfor."Nosuchthingasahousewife"isbasedonthepopulartheatreperformance"TheHousewifeMonologues".